The mission of the Walter Reed Army Institute of Research (WRAIR) Branch of Experimental Therapeutics (ET) is to discover and develop new therapeutic agents to protect military members from death, disease, and injury. The Branch is the nation’s primary developer of new drugs to prevent and/or treat malaria and leishmaniasis. Collectively, ET engages in drug discovery, drug efficacy and mechanism evaluation, and formal preclinical and clinical development for antiviral, antiparasitic, and antibacterial compounds.
WRAIR ET focuses on the discovery and development of novel therapeutics to combat or otherwise treat specific biological and/or environmental threats to the warfighter. This is carried out through the integration of modern drug design and classical medicinal chemistry, and includes global surveillance of drug resistance, investigation of drug efficacy, toxicity, and pharmacokinetics/pharmacodynamics through in vitro and in vivo testing. Additionally they plan, coordinate, and execute basic and advanced research into the design, synthesis and development of novel chemical entities to inhibit, combat or otherwise treat specific biological and/or environmental threats to the warfighter. GDIT is seeking a SeniorMedicinal Chemist to support WRAIR’s ET program by conducting the following tasks:
Provide medicinal chemistry subject matter expertise to support drug discovery and development efforts in ET/WRAIR
Coordinate with multidisciplinary teams to integrate and apply medicinal chemistry techniques to drug discovery, drug advancement, and study design of research programs in ET.
Provide strategic advice to Branch and Center leadership based on extensive pharmaceutical industry experience for the identification, characterization, and development of new drugs to protect the Warfighter.
Elucidate structure activity relationships using multi-parameter analysis
Design compounds for drug development projects based on chemical series structure activity relationships and/or literature precedence.
Prioritize compounds for in vitro and in vivo biological and ADME assessment.
Possess thorough understanding of relevant animal models of efficacy and toxicity, and actively contribute to study design and dosing regimen.
Produce effective reports and presentations to communicate experimental progress and results for internal and external purposes.
Actively seek and author/coauthor research proposals, solicitations, and other vehicles to solicit financial support to meet ET/WRAIR mission/portfolio needs.
Identify, foster, and manage internal and external collaborations with other government agencies, non-profits, academics, and private-sector research organizations and companies in order to establish and maintain a pipeline of therapeutic drugs
Meet on a weekly basis with key administrative and technical staff to set performance tasks, report progress, and troubleshoot technical issues
Ph.D. in organic chemistry, medicinal chemistry, or related discipline with experience working in the pharmaceutical industry.
10 years of drug development project management experience with medicinal chemistry expertise leading multiple projects from hit to lead stage to near pre-clinical development. The contractor shall have experience working for a government agency, preferably DoD or pharmaceutical industry.
Expert working knowledge of organic and medicinal chemistry. Provide thorough understanding of pharmacokinetics, pharmacology, toxicology, drug design, use of in silico tools, ability to interpret in vivo results, drug discovery process, purification techniques, and ability to analyze target compound spectra obtained by analytical instruments to characterize compounds such as nuclear magnetic resonance (NMR), infrared spectrometry (IR), mass spectrometry (MS), and elemental analysis.
Able to use Microsoft Office programs including Word, Excel, PowerPoint, ChemDraw and should be familiar with SAR vision, Vortex, or some other suitable chemical mapping/analysis software programs. Experience publishing scientific papers in a peer reviewed recognized medicinal/ chemistry journals and/or patents and/or submitting pre-proposals and/or proposals for internal or external funding.
Mentor synthetic chemists and provide written feedback for annual performance reviews of synthetic chemists.
Work may involve long periods of standing.
Office environment; may require working evenings and weekends.
Must be a US citizen with the ability to obtain a favorable NACI T1 security investigation.
We are GDIT. The people supporting some of the most complex government, defense, and intelligence projects across the country. We deliver. Bringing the expertise needed to understand and advance critical missions. We transform. Shifting the ways clients invest in, integrate, and innovate technology solutions. We ensure today is safe and tomorrow is smarter. We are there. On the ground, beside our clients, in the lab, and everywhere in between. Offering the technology transformations, strategy, and mission services needed to get the job done.
GDIT is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status, or any other protected class.