Bioanalytical Scientist

Clearance Level
None
Category
Scientists
Location
Silver Spring, Maryland

REQ#: RQ90130

Travel Required: Less than 10%
Public Trust: NACLC (T3)
Requisition Type: Regular
Job Description

GDIT is seeking a Bioanalytical Scientist to support the Walter Reed Army institute of Research’s Experimental Therapeutics Branch. This position will support the research and any activities needed to most efficiently advance lead candidate drugs to the next level of testing and ultimately FDA approval. Specific duties include:

In this role, a typical day will include:

  • Assist with the development and validation of analytical methods for the identification of candidate new drugs and putative metabolites using HPLC with UV/VIS, radioactive monitor analyses, and/or mass spectrometry as needed.
  • Assist with the characterization of metabolites formation and metabolic profiles of candidate drugs using in vivo and in vitro techniques as needed. Prepare samples to be assayed using both manual and robotic/high-throughput means.
  • Use in vitro techniques (liver microsomes, hepatocytes, slices) to assess for potential metabolism-based drug-drug interactions involving hepatic P450 enzymes.
  • Assist with the design and implementation of cytotoxicity and permeability studies involving the use of cell cultures under aseptic techniques.
  • Maintain and troubleshoot HPLC and mass spectrometry systems, a robotic liquid handling system, and basic pharmacology/toxicology laboratory equipment.
  • Maintain appropriate data records and notebooks.
  • Prepare biological samples for analysis using methods to include tissue homogenization, blood spot filter puncture, and solvent extraction.
  • Conduct ELISA assays in support of pharmacokinetic and biomarker studies.
  • Perform chemical derivitization reactions when required for analyte detection.
  • Conduct in vitro assays using TECAN Liquid Handling systems.
  • Assist in manual tasks including, but not limited to, filling liquid nitrogen dewars and tanks for use in laboratory operations, biohazard disposal, and acquisition/return of gas tanks from the logistics facility.
  • Assist in chemical and supply inventories and laboratory organization as requested.
  • Present novel laboratory findings at a nationally recognized scientific meeting and submit for publication in peer-reviewed journals.
  • Assist with the initiation and tracking of purchase request, and service calls through Medical Maintenance Branch.
  • Comply with all specified guidelines regarding safety, security, standard operating procedures, written protocols, technical manuals, and procurement of supplies/equipment as per WRAIR regulations

Required:

  • BS in Chemistry, Biology, or related field with relevant bioanalytical coursework
  • 2+ years of experience analytical chemistry
  • Working knowledge of HPLC analysis and familiarity with the handling of biological samples.
  • Experience with basic MS Office (or compatible) software for generating reports and summaries for presentations, managing data spreadsheets, requesting supplies and materiel as needed to perform general laboratory maintenance.
  • Experience with metabolism related studies, along with troubleshooting and basic maintenance of mass spectrometry equipment
  • Excellent organizational and interpersonal skills as well as good written and oral communication.
  • Must be a US citizen with the ability to obtain a favorable NACI T1 security investigation.

WHAT GDIT CAN OFFER YOU:

  • 401K with company match
  • Customizable health benefits packages
  • Internal mobility team dedicated to helping you own your career
  • Challenging work that makes a real impact on the world around you
  • Full-flex work week
We are GDIT. The people supporting some of the most complex government, defense, and intelligence projects across the country. We deliver. Bringing the expertise needed to understand and advance critical missions. We transform. Shifting the ways clients invest in, integrate, and innovate technology solutions. We ensure today is safe and tomorrow is smarter. We are there. On the ground, beside our clients, in the lab, and everywhere in between. Offering the technology transformations, strategy, and mission services needed to get the job done.

GDIT is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status, or any other protected class.