Structural Biologist

Clearance Level
Silver Spring, Maryland

REQ#: RQ71186

Travel Required: Less than 10%
Public Trust: NACI (T1)
Requisition Type: Regular
GDIT is seeking a Structural Biology Scientist in support of the Walter Reed Army Institute of Research (WRAIR) Bacterial Diseases Branch, in the Wound Infections Department (WID). The mission of this department is to defeat combat related wound infections and research efforts are focused delivering novel solutions as prophylactics and/or treatments for combating Multidrug-resistant (MDR) infections.Duties include, but not limited to:
  • Principal investigator with scientific and technical skills for the research and development of novel medical countermeasures against wound infections.
  • Design and perform research on structure based drug design for microbial pathogens of military relevance and animal testing
  • Develop and recommend drug candidates for specific targets on ESKAPEE pathogens (Enterococcus species, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae, and Escherichia coli) for antimicrobial development and approval by the team lead and department chief.
  • Draft grant proposals on structure based drug design for submission and approval by the department chief and research steering.
  • Conduct research on projects associated with antimicrobial development such as protein expression and purification, MIC (minimum inhibitory concentration experiments, animal modeling, virtual modeling of drugs bound to target proteins, etc.
  • Deliver novel small molecules and peptides, express, purify and crystallize proteins for structure-based drug design, and mass spectrometry of all products.
  • Serve as technical expert in the expression and purification of bacterial and host proteins.
  • Serve as technical expert in the determination of the molecular structure of bacterial and host proteins by X‐ray crystallography or other methods.
  • Serve as the technical expert in the evaluation of structure‐function relationships involving bacterial, host, and small‐ or large‐molecule countermeasures
  • Draft research protocols and grant proposals for scientific review and conduct the approved research.
  • Observe, instruct, and validate technician performance.
  • Keep accurate and complete records of research done in accordance with contract requirements to include modifications.
  • Submit reports and data summaries as requested and prepare research results for presentation and publication in the scientific literature.
  • Comply with occupational health and safety standards and other applicable regulations and guidelines which may include medical surveillance.
  • Attend and participate in seminars, scientific conferences, and meetings.
Minimum Qualifications:
  • MD or Ph.D. in Microbiology, chemistry, physical chemistry, Physiology, Molecular Biology, Biochemistry or other related scientific field.
  • Experience in at least one of the following areas: protein chemistry, purification methods,  animal models, and structural biology, x-ray crystallography, biophysical techniques


We are GDIT. The people supporting some of the most complex government, defense, and intelligence projects across the country. We deliver. Bringing the expertise needed to understand and advance critical missions. We transform. Shifting the ways clients invest in, integrate, and innovate technology solutions. We ensure today is safe and tomorrow is smarter. We are there. On the ground, beside our clients, in the lab, and everywhere in between. Offering the technology transformations, strategy, and mission services needed to get the job done.

GDIT is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status, or any other protected class.